Population Stratification in Genetic Association Studies
نویسندگان
چکیده
منابع مشابه
Population stratification and genetic association studies in South Asia
Population stratification and its influence on genetic association studies is a controversial topic. Although it has been suggested that stratification is unlikely to bias the results of association studies conducted in developed countries, convincing contrary empirical evidence has been published. However, it is in populations where historical ethnic, religious and language barriers exist that...
متن کاملTesting for genetic association in the presence of population stratification in genome-wide association studies.
Genome-wide case-control association study is gaining popularity, thanks to the rapid development of modern genotyping technology. In such studies, population stratification is a potential concern especially when the number of study subjects is large as it can lead to seriously inflated false-positive rates. Current methods addressing this issue are still not completely immune to excess false p...
متن کاملCorrection of Population Stratification in Large Multi-Ethnic Association Studies
BACKGROUND The vast majority of genetic risk factors for complex diseases have, taken individually, a small effect on the end phenotype. Population-based association studies therefore need very large sample sizes to detect significant differences between affected and non-affected individuals. Including thousands of affected individuals in a study requires recruitment in numerous centers, possib...
متن کاملCorrecting population stratification in genetic association studies using a phylogenetic approach
MOTIVATION The rapid development of genotyping technology and extensive cataloguing of single nucleotide polymorphisms (SNPs) across the human genome have made genetic association studies the mainstream for gene mapping of complex human diseases. For many diseases, the most practical approach is the population-based design with unrelated individuals. Although having the advantages of easier sam...
متن کاملGenotype-based matching to correct for population stratification in large-scale case-control genetic association studies.
Genome-wide association studies are helping to dissect the etiology of complex diseases. Although case-control association tests are generally more powerful than family-based association tests, population stratification can lead to spurious disease-marker association or mask a true association. Several methods have been proposed to match cases and controls prior to genotyping, using family info...
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ژورنال
عنوان ژورنال: Current Protocols in Human Genetics
سال: 2017
ISSN: 1934-8266,1934-8258
DOI: 10.1002/cphg.48